K 1000 TAB (600MG)

K-1000 (K1000,K 1000) chewable tablet is a combination product containing Calcium, Vitamin D3 (Cholecalciferol) and Vitamin K2 (menaquinone-7) that helps strengthen bones and aids in the treatment/prevention of osteoporosis, osteomalacia, hypo-parathyroidism and other bone disorders or to overcome deficiencies of calcium and Vitamin D3 in certain populations and disease states. It is also used to improve and maintain bone mineral density (BMD), bone health and strength.

CONTRAINDICATIONS

K-1000 must not be used in patients with: Hypersensitivity to any of the active substances (Vitamin D3 or its analogues, calcium or Vitamin K2 or its analogues). Due to calcium / cholecalciferol components, K-1000 tablets must not be used in: Hypercalcaemia and/or hypercalciuria Nephrolithiasis (Renal calculi) Hypervitaminosis D Severe renal impairment Metastatic calcification

WARNINGS AND PRECAUTIONS

This product should not be used in certain medical conditions, including: High calcium/Vitamin D3 levels (hypercalcemia/hypervitaminosis D) Fat mal-absorption syndromes as the absorption of Vitamin K2 is fat-dependent Known allergy to calcium, Vitamin D3 or Vitamin K2 containing products Cardiovascular disease (Heart/blood vessel disease). There is a risk of potential exacerbation of cardiac disorders and arteriosclerosis related to persistent hypercalcemic effects during therapeutic use of calcium/Vitamin D3 products. Renal calculi (Kidney stones) Renal diseases (Kidney disease). Cholecalciferol should be used with caution in patients with impairment of renal function due to the potential exacerbation of hypercalcemic effects during therapeutic use. The effect on calcium and phosphate levels should also be monitored. The risk of soft tissue calcification should be taken into account. In patients with severe renal insufficiency, Vitamin D3 in the form of cholecalciferol is not metabolized normally and other forms of Vitamin D3 should be used. Certain immune system disorder (Sarcoidosis). Cholecalciferol should be prescribed with caution to patients suffering from sarcoidosis because of the risk of increased metabolism of Vitamin D3 to its active form. These patients should be monitored with regard to the calcium content in serum and urine. Liver disease. In patients with liver impairment, Vitamin D3 absorption may be markedly impaired; conversion to active metabolite calcifediol may be reduced significantly, with the requirement of high doses of cholecalciferol. Agents not requiring hepatic hydroxylation are preferred in this condition. It is not reasonable to use cholecalciferol in severe liver impairment. Certain bowel diseases (Crohn's disease, whipple's disease) that may cause fat mal-absorption and impair the absorption of Vitamin K2 Hyperlipidemia: Cholecalciferol may cause a potential exacerbation of LDL elevation Low levels of bile/biliary obstruction that may lead to fat mal-absorption and impair the absorption of Vitamin K2 Untreated phosphate imbalance. There is a risk of metastatic calcification; normalization of phosphate levels is indicated prior to therapy with cholecaciferol. Do not exceed the recommended dose. Pregnant or breast-feeding women shall consult health care professional before use. Please consult your pharmacist/doctor before taking this medicine

ADVERSE REACTIONS COMMON:

Constipation or stomach upset may occur. Uncommon: Hypercalcemia/hypercalciuria, Nausea/vomiting, loss of appetite, unusual weight loss, mental/mood changes, change in the amount of urine, bone/muscle pain, headache, increased thirst, increased urination, weakness, tiredness, fast/pounding heartbeat. Rare: Serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

DRUG INTERACTIONS

Calcium can decrease the absorption of other drugs such as tetracycline antibiotics (e.g., doxycycline, minocycline), bisphosphonates (e.g., alendronate), estramustine, levothyroxine, and quinolone antibiotics (e.g., ciprofloxacin,

BENEFITS

Calcium rightly absorbs with K2 which helps tackle calcium deficiency in women specially for expecting women

INSTRUCTIONS

Use as advised by the physician. Keep out of the reach of children. Protect from light, heat and moisture. Store below 30°C